Bitters vary in impact from gentle bitters like Chamomile to intense bitters like Wormwood or Gentian. The entire bitters class of herbs has a variable therapeutic margin. The extra gentle the bitter the higher the therapeutic vary and the more intense the bitter the extra restrictive the range. Intense bitters like Wormwood, Tansy, and Rue have a low therapeutic margin and should be used with care. Absinthinn present in Artemisias such as Wormwood is so bitter it can be tasted at a dilution of 1:30,000. A gentle bitter like Chamomile has a really extensive therapeutic margin and can be used …